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HbA1c Targets Should Be Tailored To Individuals

HbA1c targets for people with type 2 diabetes should be tailored to individual patients and take account of both potential benefits and harms, recommend the authors of the latest Cochrane review comparing the merits of intensive versus conventional glycaemic control (Cochrane Database of Systematic Reviews 2011, Issue 6).

The analysis showed no significant differences in all-cause mortality and cardiovascular mortality (relative risks 1.01 and 1.06, respectively) for approaches which targeted intensive glycaemic control versus those targeting conventional control. Targeting intensive glycaemic control did reduce microvascular complications (RR 0.89, 95 per cent confidence interval 0.83 to 0.95; P=0.0006), but at the cost of increased hypoglycaemia. There was also evidence that intensive glycaemic control could reduce non-fatal myocardial infarction in usual care settings.

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Extract taken from PJ Online